Neutralizing antibodies in patients with severe acute respiratory syndrome: Associated coronavirus infection
Identifieur interne : 005B00 ( Main/Exploration ); précédent : 005A99; suivant : 005B01Neutralizing antibodies in patients with severe acute respiratory syndrome: Associated coronavirus infection
Auteurs : YUCHUN NIE [République populaire de Chine] ; GUANGWEN WANG [République populaire de Chine] ; XUANLING SHI [République populaire de Chine] ; HONG ZHANG [République populaire de Chine] ; YAN QIU [République populaire de Chine] ; ZHONGPING HE [République populaire de Chine] ; WEI WANG [République populaire de Chine] ; GEWEI LIAN [République populaire de Chine] ; XIAOLEI YIN [République populaire de Chine] ; LIYING DU [République populaire de Chine] ; LILI REN [République populaire de Chine] ; JIANWEI WANG [République populaire de Chine] ; Xiong He [République populaire de Chine] ; Taisheng Li [République populaire de Chine] ; Hongkui Deng [République populaire de Chine] ; Mingxiao Ding [République populaire de Chine]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background. Severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is the principal etiologic agent of SARS. We analyzed serum samples obtained from 623 patients with SARS in Beijing, to determine whether infection with SARS-CoV can elicit neutralizing antibodies (NAbs). Methods. We developed a highly sensitive and safe neutralization assay using the SARS-CoV pseudotyped virus and used this assay to determine the titers of the NAbs in serum samples from patients with SARS. Results. We found that 85.9% of serum samples contained NAbs against SARS-CoV and that most of the NAb activities could be attributed to immunoglobulin G. The NAbs became detectable first at 5-10 days after the onset of symptoms, and their levels peaked at 20-30 days and then were sustained for >150 days. The serum samples could neutralize the pseudotype particles bearing the spike glycoproteins from different SARS-CoV strains, suggesting that the NAbs to SARS-CoV were broadly reactive. Conclusions. NAbs to SARS-CoV are broadly elicited in patients with SARS and, according to their kinetics, may correlate with viral load during the early stages of the disease. These results suggest that it is possible to develop effective vaccines against SARS and that NAbs provide a potential strategy for treating patients with SARS.
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Neutralizing antibodies in patients with severe acute respiratory syndrome: Associated coronavirus infection</title><author><name sortKey="Yuchun Nie" sort="Yuchun Nie" uniqKey="Yuchun Nie" last="Yuchun Nie">YUCHUN NIE</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Guangwen Wang" sort="Guangwen Wang" uniqKey="Guangwen Wang" last="Guangwen Wang">GUANGWEN WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Xuanling Shi" sort="Xuanling Shi" uniqKey="Xuanling Shi" last="Xuanling Shi">XUANLING SHI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Hong Zhang" sort="Hong Zhang" uniqKey="Hong Zhang" last="Hong Zhang">HONG ZHANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Beijing Red Cross Blood Center</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhongping He" sort="Zhongping He" uniqKey="Zhongping He" last="Zhongping He">ZHONGPING HE</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Ditan Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>6 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wei Wang" sort="Wei Wang" uniqKey="Wei Wang" last="Wei Wang">WEI WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Gewei Lian" sort="Gewei Lian" uniqKey="Gewei Lian" last="Gewei Lian">GEWEI LIAN</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Xiaolei Yin" sort="Xiaolei Yin" uniqKey="Xiaolei Yin" last="Xiaolei Yin">XIAOLEI YIN</name><affiliation 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Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Lili Ren" sort="Lili Ren" uniqKey="Lili Ren" last="Lili Ren">LILI REN</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Xiong" sort="He, Xiong" uniqKey="He X" first="Xiong" last="He">Xiong He</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Beijing Municipal Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>14 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Ding, Mingxiao" sort="Ding, Mingxiao" uniqKey="Ding M" first="Mingxiao" last="Ding">Mingxiao Ding</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 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type="wicri:Area/Main/Exploration">005B00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neutralizing antibodies in patients with severe acute respiratory syndrome: Associated coronavirus infection</title><author><name sortKey="Yuchun Nie" sort="Yuchun Nie" uniqKey="Yuchun Nie" last="Yuchun Nie">YUCHUN NIE</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Guangwen Wang" sort="Guangwen Wang" uniqKey="Guangwen Wang" last="Guangwen Wang">GUANGWEN WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Xuanling Shi" sort="Xuanling Shi" uniqKey="Xuanling Shi" last="Xuanling Shi">XUANLING SHI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Hong Zhang" sort="Hong Zhang" uniqKey="Hong Zhang" last="Hong Zhang">HONG ZHANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Beijing Red Cross Blood Center</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhongping He" sort="Zhongping He" uniqKey="Zhongping He" last="Zhongping He">ZHONGPING HE</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Ditan Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>6 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wei Wang" sort="Wei Wang" uniqKey="Wei Wang" last="Wei Wang">WEI WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Gewei Lian" sort="Gewei Lian" uniqKey="Gewei Lian" last="Gewei Lian">GEWEI LIAN</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Xiaolei Yin" sort="Xiaolei Yin" uniqKey="Xiaolei Yin" last="Xiaolei Yin">XIAOLEI YIN</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Liying Du" sort="Liying Du" uniqKey="Liying Du" last="Liying Du">LIYING DU</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Lili Ren" sort="Lili Ren" uniqKey="Lili Ren" last="Lili Ren">LILI REN</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Xiong" sort="He, Xiong" uniqKey="He X" first="Xiong" last="He">Xiong He</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Beijing Municipal Center for Disease Control and Prevention</s1><s2>Beijing</s2><s3>CHN</s3><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>14 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author><author><name sortKey="Ding, Mingxiao" sort="Ding, Mingxiao" uniqKey="Ding M" first="Mingxiao" last="Ding">Mingxiao Ding</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cell Biology and Genetics, College of Life Sciences, Peking University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Human</term><term>Infection</term><term>Microbiology</term><term>Neutralizing antibody</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Coronavirus</term><term>Anticorps neutralisant</term><term>Microbiologie</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is the principal etiologic agent of SARS. We analyzed serum samples obtained from 623 patients with SARS in Beijing, to determine whether infection with SARS-CoV can elicit neutralizing antibodies (NAbs). Methods. We developed a highly sensitive and safe neutralization assay using the SARS-CoV pseudotyped virus and used this assay to determine the titers of the NAbs in serum samples from patients with SARS. Results. We found that 85.9% of serum samples contained NAbs against SARS-CoV and that most of the NAb activities could be attributed to immunoglobulin G. The NAbs became detectable first at 5-10 days after the onset of symptoms, and their levels peaked at 20-30 days and then were sustained for >150 days. The serum samples could neutralize the pseudotype particles bearing the spike glycoproteins from different SARS-CoV strains, suggesting that the NAbs to SARS-CoV were broadly reactive. Conclusions. NAbs to SARS-CoV are broadly elicited in patients with SARS and, according to their kinetics, may correlate with viral load during the early stages of the disease. These results suggest that it is possible to develop effective vaccines against SARS and that NAbs provide a potential strategy for treating patients with SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement><orgName><li>Université de Pékin</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yuchun Nie" sort="Yuchun Nie" uniqKey="Yuchun Nie" last="Yuchun Nie">YUCHUN NIE</name></noRegion><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><name sortKey="Ding, Mingxiao" sort="Ding, Mingxiao" uniqKey="Ding M" first="Mingxiao" last="Ding">Mingxiao Ding</name><name sortKey="Gewei Lian" sort="Gewei Lian" uniqKey="Gewei Lian" last="Gewei Lian">GEWEI LIAN</name><name sortKey="Guangwen Wang" sort="Guangwen Wang" uniqKey="Guangwen Wang" last="Guangwen Wang">GUANGWEN WANG</name><name sortKey="He, Xiong" sort="He, Xiong" uniqKey="He X" first="Xiong" last="He">Xiong He</name><name sortKey="Hong Zhang" sort="Hong Zhang" uniqKey="Hong Zhang" last="Hong Zhang">HONG ZHANG</name><name sortKey="Jianwei Wang" sort="Jianwei Wang" uniqKey="Jianwei Wang" last="Jianwei Wang">JIANWEI WANG</name><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><name sortKey="Lili Ren" sort="Lili Ren" uniqKey="Lili Ren" last="Lili Ren">LILI REN</name><name sortKey="Liying Du" sort="Liying Du" uniqKey="Liying Du" last="Liying Du">LIYING DU</name><name sortKey="Wei Wang" sort="Wei Wang" uniqKey="Wei Wang" last="Wei Wang">WEI WANG</name><name sortKey="Xiaolei Yin" sort="Xiaolei Yin" uniqKey="Xiaolei Yin" last="Xiaolei Yin">XIAOLEI YIN</name><name sortKey="Xuanling Shi" sort="Xuanling Shi" uniqKey="Xuanling Shi" last="Xuanling Shi">XUANLING SHI</name><name sortKey="Yan Qiu" sort="Yan Qiu" uniqKey="Yan Qiu" last="Yan Qiu">YAN QIU</name><name sortKey="Zhongping He" sort="Zhongping He" uniqKey="Zhongping He" last="Zhongping He">ZHONGPING HE</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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